BFS Three-in-one Plastic Ampoule Forming, Liquid Filling and Sealing Machine

Model Number: BFS Brand Name: SPM Key Specifications/Special Features: Definition:BFS is the abbreviation for blow-fill-seal, This technology accomplished the plastic ampoule forming, liquid filling and the plastic ampoule sealing through the process of continuous operation of a device. All of these processes in aseptic condition are completed in one time, the cycle time is 12-14 seconds.BFS technology has been used for about 40 years in the world. The pollution rate by verification can reach 0.1%. According to the summary and analysis of the medium filling data, the pollution rate of BFS system is 0.001%.Characteristics:The biggest advantage of BFS is reduce outer pollution —human contamination, environment pollution and material pollution, which can be sure product safety .Package
The process is versatile and a wide variety of containers of different sizes can be made on the machine. The size may range from 0.2ml to 13 liters. For convenience, the sizes of containers are classified in the following three categories:
-Small volume packaging: For containers from 0.2ml up to volume of 50ml.
-Large volume packaging: For containers from 50ml up to 500ml.
-Very large volume packaging: For containers above 2500ml.

There are two structure type of BFS machine, black/white zoning and without black/white zoning.
1. BFS machine conforms to Black/White zoning configuration and this module configuration separates filling (white zone)
from auxiliary device zone (black zone). All particles source are placed into auxiliary device zone (black zone). Auxiliary device
zone to filling zone (white zone) keeps negative pressure, so the clean room space decreases greatly.

2. BFS machine conforms to without Black/White zoning configuration and this configuration is to be the entire device placed
in the C class zone. This structure occupied clean area is relatively large, but the overall size of the device is relatively small.

Development Tendency
The process of BFS is not only with the requirements of GMP, but also is the development trend of sterile drug products in China. The BFS technology which will replace glass ampoules and glass bottle infusion will become the mainstream of sterile drug products.

1. The mould is transferred to blowing/filling station quickly. The blowing/filling/sealing
mandrels are protected against contamination by sterile air in the aseptic air chamber. The blowing /filling nozzle is lowered into the parison until it forms a seal with the neck
of the mold. The plastic material is now formed into a container as determined by the design of the mould by vacuum and /or sterile air pressure.